SINDROME METABOLICO

1: Kardiologiia. 2007;47(1):11-5.
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[Visceral obesity as a pathogenetic factor of ischemic heart disease]
[Article in Russian]
Sokolov EI,
Pisarevskaia AL.
Relationship between visceral obesity and development of ischemic heart disease (IHD) has been widely studied during last years. Fat tissue is considered to be endocrine and secretory organ liberating wide spectrum of protein and signal factors-adipokines. We studied 27 healthy subjects and 55 patients (including 39 patients with IHD) with visceral and gynoid obesity. Abdominal fat content was assessed quantitatively by computed tomography. It was proven that total volume of fat tissue in visceral obesity is substantially elevated especially in mesogastrium, omentum, and around portal vein, where increased amounts of very low density lipoproteins, free fatty acids, and low density lipoproteins are generated. Enhanced inflow of free fatty acids and glucose to liver constitutes pathophysiologic basis of visceral obesity. This very process creates elevation of optical density of tissue in visceral obesity. Elevation of low density lipoproteins, very low density lipoproteins, and cholesterol are important factors in pathogenesis of IHD.
PMID: 17426675 [PubMed - indexed for MEDLINE]
TRADUCCION: La relación entre obesidad visceral y el desarrollo de enfermedad isquémica cardíaca ha sido ampliamente estudiada durante los últimos años . El tejido adiposo es considerado un o´rgano endocrino y secretorio liberando un amplio espectro de proteínas y citoquinas, Nosotros estudiamos 55 pacientes ( incluyendo 39 pacientes con cardiopatía isquémica con obesidad visceral y ginoide. La cantidad de grasa abdominal fue evaluada con tomografñía computada. Fue provado que el volumen tortal de tejido adiposo abdominal esta sustancialmente elevado especialmente en mesogastrio, omentum y alrededor de la vena porta donde elevadas cantidades de lipoproteínas, ácidos grasos libres, y lipoproteínas de baja densidad son producidas. Este proceso crea elevación de la densidad óptica del tejido en la región visceral. la elevación de lipoproteínas de baja densidad , muy baja densidad y colesterol son importantes factores en la patogenia de la cardiopatía isquémica.