ENVEJECIMIEENTO MASCULINO

1: Menopause. 2007 May 24; [Epub ahead of print]
Testosterone correlated to symptoms of partial androgen deficiency in aging men (PADAM) in an elderly Swedish population.
· Spetz AC,
· Palmefors L,
· Skobe RS,
· Stromstedt MT,
· Fredriksson MG,
· Theodorsson E,
· Hammar ML.
From the Divisions of 1Obstetrics and Gynaecology, 2Occupational and Environmental Medicine, and 3Clinical Chemistry, Faculty of Health Sciences, University Hospital, Linkoping, Sweden.
OBJECTIVE:: To investigate the prevalence of different symptoms of partial androgen deficiency in aging men (PADAM) and to correlate them with blood concentrations of testosterone and bioavailable testosterone. DESIGN:: A total of 370 men, aged 55 to 75 years, were invited to one of three primary healthcare centers in Sweden. They were asked to complete a questionnaire regarding demographic data, medical history, mood status, medication, castration therapy and smoking, exercise and alcohol habits, as well as different symptoms of PADAM. The 10 questions from a previously used questionnaire (the ADAM questionnaire) were included. The men were offered blood tests for analyses of testosterone, follicle stimulating hormone, luteinizing hormone, steroid hormone-binding globulin, and albumin. From these test results, we calculated the bioavailable testosterone. RESULTS:: Of the questionnaires sent out, 81.6% were returned and eligible for evaluation. Blood samples were obtained from 85.8% of men answering the questionnaire. Many of the symptoms, including five from the ADAM questionnaire, were more common in older age groups (P < 0.05). Three symptoms, deterioration in work performance, decreased strength and/or endurance, and bothersome hot flushes, were associated with low bioavailable testosterone and/or testosterone (P < 0.05). Testosterone and bioavailable testosterone did not differ between age groups, but bioavailable testosterone was higher in men with three or fewer symptoms on the ADAM questionnaire. CONCLUSIONS:: Symptoms associated with PADAM often occur in an elderly population, but we could only find an association between three symptoms and blood testosterone concentrations, one being bothersome hot flushes. It is likely that these symptoms have a more complex background than only PADAM.
PMID: 17529900 [PubMed - as supplied by publisher]
TRADUCCION . TESTOSTERONA SE CORRELACIONA CON SINTOMAS DE PARCIAL DEFICIENCIA DE ANDROGENOS EN EL HOMBRE VIEJO (PADAM)EN UNA POBLACION VIEJA SUECA Spetz AC,
From the Divisions of 1Obstetrics and Gynaecology, 2Occupational and Environmental Medicine, and 3Clinical Chemistry, Faculty of Health Sciences, University Hospital, Linkoping, Sweden.
OBJETIV0. Investigar la prevalencia de de diferentes sintomas de deficiencia parcial de andrógenos en el hombre viejo (PADAM) y correlacionarlos con las concentraciones plasmáticas de testosterona y testosterona biodisponible. Diseño : fue invitado un total de 370 hombres entre 55 y 75 años a uno de los Centros de Salud Primaria en su Suecia. Los varones fueron invitados a contestar un cuestionario considerando datos demográficos,historia médica, animo,medicamentos , terapia de castración cigarrillo ejercicio, consumo de alcohola su vez que diferentes síntomas de PADAM. . les fue ofrecido a los varones la determinación de testosterona total, FSH, LH, SHBGy albúmina. De estos tests fue determinado la testosterona biodisponible. RESULTADOS. Retonaron el 81,6 % de los cuestionarios enviados. Muestras de sangre fueron obtenidas del 85,8%de los varones. Quienes contestaron el cuestionario. . Muchos de síntomas incluyendo 5 del cuestionario ADAM fueron mas frecuentes en hombres viejos (P < 0.05). Tres síntomas, como deterioro del rendimiento en el trabajo, disminución de la fuerza musculary o resistencia, y bochornos molestos fueron asociados a bajos niveles de testosterona biodisponible y/otestosterona total (P < 0.05).. testosterona total y biodisponible no difirieron entre los grupos de edad, pero la testosterona biodisponible fue mas alta en varones con 3 o menos síntomas del cuestionario ADAM. CONCLUSION. Los síntomas del cuestionario ADAM generalmente ocurren en la población vieja pero nosotros pudimos solo encontrar una asociación entre los 3 síntomas y los niveles de testosterona una de ellas fueron los bochornos. Es probable que estos síntomas tengan un backgroundmas complejoque solo el PADAM.